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Sildenafil (Viagra) was the first oral phosphodiesterase type 5 (PDE5) inhibitor approved by the FDA in the United States for the treatment of erectile dysfunction (it is not approved for women). Sildenafil inhibits PDE5, which is an enzyme that destroys cGMP. By inhibiting the destruction of cGMP by PDE5, sildenafil allows cGMP to accumulate. The cGMP in turn prolongs relaxation of the smooth muscle of the corpora cavernosa. Relaxation of the corpora cavernosa smooth muscle allows blood to flow into the penis resulting in increased engorgement of the penis. In short, sildenafil increases blood flow into the penis and decreases blood flow out of the penis. Erectile dysfunction, heart disease and other vascular diseases: Certain risk factors increase the risk of more atheroma forming which can make atheroma-related conditions worse. These are discussed in more detail in another leaflet called 'Preventing Cardiovascular Diseases'. Briefly, risk factors that can be modified and may help to prevent atheroma-related conditions from getting worse are: Smoking. Smoking is one of the biggest risk factors for developing an atheroma-related condition. Smoking roughly doubles your chance of developing ED. Young smokers may not be aware that they have a much greater risk of developing ED by middle age compared with nonsmokers. If you smoke, make every effort to stop. High blood pressure. Make sure your blood pressure is checked at least once a year. If it is high, it can be treated. If you are overweight, losing some weight is advised. A high cholesterol. This can be treated if it is high. Inactivity. We should all aim to do some moderate physical activity on most days of the week for at least 30 minutes. For example, brisk walking, swimming, cycling, dancing, gardening, etc. Diet. Aim to eat a healthy diet. Details in a separate leaflet called 'Healthy Eating'. Alcohol excess. Diabetes. If you have diabetes, good control of the blood sugar level and blood pressure can help to minimise the impact of diabetes on the blood vessels. viagra online japan viagra Simpler and cheaper to order viagra on the Internet from an online drugstore and to you all will bring home. online viagra online singapore buy viagra without prescription How should tadalafil (Cialis) be administered? The recommended starting dose of tadalafil for most patients is 10 mg taken orally approximately one hour before sexual activity. The dose may be adjusted higher to 20 mg or lower to 5 mg depending on efficacy and tolerability. The maximum recommended dosing frequency is once per day, although for many patients tadalafil can be taken less frequently since the improvement in erectile function may last 36 hours. Tadalafil may be taken with or without food. is it illegal to buy viagra online in australia viagra online Therefore, men with these conditions should not use vardenafil without having these conditions evaluated and stabilized first. For example, men with uncontrolled high blood pressure should have their blood pressure controlled; and men with potentially life-threatening abnormal heart rhythms should have these rhythms controlled. buy cialis online prescription buy cheap cialis

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